The RIG-I-like receptor (RLR) pathway detects viral RNA, triggering the production of type I interferons (IFNα/β) that are crucial for initiating an innate antiviral immune response. Through systematic assessment of a wide variety of available genomics data, we identified 10 molecular signatures of RLR pathway components that are collectively able to predict novel members. Bayesian integration of the RLR signatures led to the identification of novel RLR pathway components. We have validated an effect on RIG-I-mediated IFNβ induction for many of the predictions.
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Robin van der Lee | Martijn A. Huynen |
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Centre for Molecular and Biomolecular Informatics
Radboud Institute for Molecular Life Sciences
Radboud university medical center
Nijmegen, The Netherlands
The Virgo consortium, funded by the Dutch government (FES0908), and by the Netherlands Genomics Initiative (050-060-452).