Genome-wide prioritization of RIG-I-like receptor (RLR) pathway components
The RIG-I-like receptor (RLR) pathway detects viral RNA, triggering the production of type I interferons (IFNα/β) that are crucial for initiating an innate antiviral immune response. Through systematic assessment of a wide variety of available genomics data, we identified 10 molecular signatures of RLR pathway components that are collectively able to predict novel members. Bayesian integration of the RLR signatures led to the identification of novel RLR pathway components. We have validated an effect on RIG-I-mediated IFNβ induction for many of the predictions.
If you found this resource useful, we would be grateful if you could cite:
Robin van der Lee, Qian Feng, Martijn A. Langereis, Rob ter Horst, Radek Szklarczyk, Mihai G. Netea, Arno C. Andeweg, Frank J. M. van Kuppeveld, and Martijn A. Huynen (2015)
Integrative genomics-based discovery of novel regulators of the innate antiviral response
PLoS Computational Biology
11(10): e1004553, doi:10.1371/journal.pcbi.1004553
How to use the data table?
- Download the full data (.xlsx table, ~6 MB) using the download button (bottom left).
- Click on a Uniprot or Entrez identifier to visit the corresponding Uniprot or Entrez web pages.
- Filter using the seach boxes; change search options by clicking on the icons to left of the search boxes.
- Combine search queries using the magnifying glass icon (bottom left).
- Sort by clicking on the column headers.
- Click on a row to expand its information; click again to collapse it.
- InnateDB annotations provide summaries of the role of a gene in innate immunity, PubMed IDs are shown within brackets.
Centre for Molecular and Biomolecular Informatics
Radboud Institute for Molecular Life Sciences
Radboud university medical center
Nijmegen, The Netherlands
The Virgo consortium, funded by the Dutch government (FES0908), and by the Netherlands Genomics Initiative (050-060-452).