Genome-wide prioritization of RIG-I-like receptor (RLR) pathway components


The RIG-I-like receptor (RLR) pathway detects viral RNA, triggering the production of type I interferons (IFNα/β) that are crucial for initiating an innate antiviral immune response. Through systematic assessment of a wide variety of available genomics data, we identified 10 molecular signatures of RLR pathway components that are collectively able to predict novel members. Bayesian integration of the RLR signatures led to the identification of novel RLR pathway components. We have validated an effect on RIG-I-mediated IFNβ induction for many of the predictions.

The above data table contains the complete resource of predicted and validated RLR pathway components.    Click here to download the .xlsx version of the table



If you found this resource useful, we would be grateful if you could cite:

Robin van der Lee, Qian Feng, Martijn A. Langereis, Rob ter Horst, Radek Szklarczyk, Mihai G. Netea, Arno C. Andeweg, Frank J. M. van Kuppeveld, and Martijn A. Huynen (2015)
Integrative genomics-based discovery of novel regulators of the innate antiviral response
PLoS Computational Biology 11(10): e1004553, doi:10.1371/journal.pcbi.1004553
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How to use the data table?



Robin van der Lee Martijn A. Huynen

Centre for Molecular and Biomolecular Informatics
Radboud Institute for Molecular Life Sciences
Radboud university medical center

Nijmegen, The Netherlands

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The Virgo consortium, funded by the Dutch government (FES0908), and by the Netherlands Genomics Initiative (050-060-452).

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